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Thyroid orbitopathy (also known as Graves’ Disease) is an autoimmune inflammatory disorder of uncertain etiology that affects the tissues of the orbit (i.e. eyelids, extraocular muscles and other soft tissues surrounding the eyes). Patients with this disorder often have an associated thyroid abnormality which may manifest either before, during or after the orbital signs and symptoms. However, a small percentage of patients may have eyelid and orbital manifestations of the disorder without developing a thyroid abnormality.
Disease Characteristics
Thyroid orbitopathy can develop and affect patients with varying degrees of severity. The disease can begin suddenly and progress rapidly over days to weeks or start insidiously and progress gradually over a long period of time. The majority of patients have mild inflammation, the most common signs and symptoms of which are retraction of the upper and/or lower eyelids and bulging of the eyes (also known as proptosis). In cases of moderate inflammation, patients may also have varying degrees of double vision and eyelid swelling as well as visible redness of the lids and eyes. A small percentage of patients with thyroid eye disease develop severe inflammation, which can result in compression of the optic nerve and permanent vision loss. In most cases, the inflammatory process is self-limited and runs a course lasting 6 months to a few years before subsiding. After the inflammatory phase of the disease subsides, scarring of eyelid and orbital tissues may result in the persistence of eyelid retraction, proptosis and double vision.
Evaluation and Management
It is important to be evaluated by an oculoplastic specialist like Dr. Fu to assess the ophthalmic manifestations of the disease, as well as by an endocrinologist to manage concurrent thyroid abnormalities. Patients with mild orbitopathy are usually evaluated on an interval basis to monitor progression of the disease and managed with measures to reduce ocular symptoms. Patients with moderate to severe orbitopathy may require medical or surgical intervention to reduce inflammation or improve vision. Once the inflammatory phase of the disease has subsided, patients with eyelid abnormalities, double-vision or proptosis may be eligible for surgical correction to improve their function and appearance. Cigarette smoking has been associated with development of worsening thyroid orbitopathy, therefore cessation of smoking is universally recommended in these patients.
As a board-certified, fellowship trained oculoplastic surgeon with extensive training and experience, Dr. Selena Fu customizes each treatment to reflect each patient’s unique anatomy, skin condition, aesthetic concerns and lifestyle— an approach that consistently delivers excellent results for her patients.
Call for a personal consultation today, Dr. Fu will discuss the surgical and non-surgical options that will provide your best possible outcome. Insurance may cover all or a portion of reconstructive surgeries.
hyroid Orbitopathy, also known as Thyroid Eye Disease (TED) or Graves’ Orbitopathy, is an autoimmune condition that affects the eye and surrounding tissues. It causes eye bulging (proptosis), eyelid retraction, double vision, dryness, and irritation due to inflammation in the eye socket. While some severe cases may require surgery, many patients can manage their symptoms with non-surgical treatments.
✔ Active (Inflammatory) Phase – This phase lasts 6 months to 2 years, during which inflammation, swelling, and rapid symptom changes occur. Treatment aims to reduce inflammation and protect vision.
✔ Stable (Chronic) Phase – Once inflammation settles, the condition stabilizes, but some patients may have persistent eye bulging or misalignment, which may require further treatment.
Most non-surgical treatments focus on reducing inflammation, managing symptoms, and preventing long-term damage.
🔹 Corticosteroids (Steroids) – High-dose oral or IV steroids (such as prednisone or methylprednisolone) help reduce swelling and pressure behind the eyes.
🔹 Teprotumumab (Tepezza®) – An FDA-approved infusion therapy that targets the immune response in TED, helping reduce eye bulging (proptosis) and inflammation.
🔹 Immunosuppressive Drugs – In severe cases, methotrexate or mycophenolate mofetil may be used to suppress the immune system.
🔹 Selenium Supplements – Studies suggest that selenium (100-200 mcg daily) may help mild cases of thyroid eye disease by reducing inflammation.
✔ Smoking Cessation – Smoking worsens TED and reduces treatment effectiveness. Quitting smoking can significantly slow the disease.
✔ Eye Lubrication – Use artificial tears, gel drops, and lubricating ointments to relieve dryness and irritation.
✔ Sleeping Position – Elevate the head while sleeping to reduce eye swelling.
✔ Cool Compresses – Helps soothe irritated and swollen eyes.
✔ Sunglasses & UV Protection – Reduces light sensitivity and protects against UV rays.
✔ If TED causes double vision (diplopia), special prism lenses can help align images and improve vision without surgery.
✔ Low-dose orbital radiation may be used to reduce swelling and eye muscle inflammation, especially when steroids alone are not effective.
⏳ Duration: Most non-surgical treatments take weeks to months to show improvement.
✔ Steroid or infusion therapy can provide noticeable relief within a few weeks.
✔ Lifestyle changes and eye care treatments help manage symptoms continuously.
⚠ Steroids – May cause weight gain, high blood sugar, mood changes, or bone loss if used long-term.
⚠ Teprotumumab (Tepezza®) – Possible side effects include muscle cramps, nausea, and temporary hearing changes.
⚠ Radiation Therapy – May cause temporary dryness or irritation.
If non-surgical treatments do not control the symptoms or the patient is left with significant eye bulging, double vision, or eyelid problems, surgery may be necessary after the disease has stabilized.
✅ Many patients experience improvement with medications, lifestyle changes, and symptom management.
🚨 However, severe cases may still require surgery to correct lasting eye changes.
✔ Most insurance plans cover steroid therapy, Tepezza®, and radiation therapy if medically necessary.
✔ Cosmetic procedures (such as botox for eyelid changes) are usually not covered.
💡 Non-surgical treatments for Thyroid Eye Disease focus on reducing inflammation, relieving symptoms, and preventing vision problems.
✅ New treatments, such as Tepezza®, have significantly improved outcomes for many patients.
📌 If you have symptoms of TED, consult an oculoplastic surgeon or endocrinologist for early treatment options.
Thyroid Orbitopathy, also known as Thyroid Eye Disease (TED) or Graves’ Orbitopathy, is an autoimmune condition that causes inflammation, swelling, and tissue expansion behind the eye, leading to bulging eyes (proptosis), double vision, eyelid retraction, and, in severe cases, vision loss. When non-surgical treatments are not enough to correct vision problems or cosmetic concerns, surgical intervention may be necessary.
Surgery is usually considered once TED has stabilized (inactive phase), which typically occurs 6 months to 2 years after the active inflammation phase. Surgery may be needed if:
✔ Eye Bulging (Proptosis) Is Severe – When the eyes protrude excessively and cannot be corrected with medication.
✔ Vision Is at Risk – Pressure on the optic nerve (compressive optic neuropathy) may lead to vision loss.
✔ Double Vision (Diplopia) Persists – When misaligned eye muscles affect daily activities.
✔ Eyelid Retraction Is Causing Discomfort or Exposure Problems – Leading to dry eyes, irritation, or incomplete eyelid closure.
✔ Cosmetic Concerns – Severe eye bulging or asymmetry affecting appearance and self-confidence.
Surgery is usually performed in three stages, depending on the severity of the disease:
🔹 Purpose: Reduces pressure inside the eye socket (orbit) by removing bone or fat, allowing the eye to move back into a normal position.
🔹 Procedure:
✔ A small incision is made inside the eyelid or through the nose to access the orbit.
✔ Bone or fat from the eye socket is removed or reshaped to relieve pressure.
✔ The surgery allows the eye to sit further back, reducing proptosis (bulging).
🔹 Recovery: Most patients resume normal activities within 2-4 weeks, with full results visible in a few months.
🔹 Purpose: Realigns the eyes to improve double vision caused by swollen or damaged muscles.
🔹 Procedure:
✔ The surgeon adjusts tightened or misaligned eye muscles to restore normal movement.
✔ Dissolvable sutures may be placed to help with eye alignment.
🔹 Recovery: Most patients see improvement in eye movement within 1-2 weeks, with final results in 3-6 months.
🔹 Purpose: Corrects eyelid position to protect the eye, improve closure, and enhance appearance.
🔹 Procedure:
✔ For upper eyelid retraction, the eyelid muscles are loosened or repositioned.
✔ For lower eyelid retraction, tissue grafts or fat injections may be used to restore support.
🔹 Recovery: Eyelid swelling resolves in 1-2 weeks, but final positioning may take a few months.
✔ Medical Evaluation & Imaging Tests – CT or MRI scans assess the extent of orbital swelling, muscle misalignment, and optic nerve compression.
✔ Surgical Plan Discussion – Your surgeon will explain the procedures and discuss the sequence of surgeries needed.
✔ Pre-Surgery Guidelines –
⏳ Duration: The surgery can take 1 to 3 hours, depending on the procedure.
✔ Anesthesia Options: General anesthesia is used for orbital decompression and muscle surgery, while eyelid surgery may be performed under local anesthesia.
✔ Surgical Incisions:
✔ Swelling & Bruising: Common for 1-2 weeks, improving gradually.
✔ Use of Cold Compresses: Helps reduce swelling in the first few days.
✔ Pain Management: Mild discomfort can be managed with over-the-counter pain relievers.
✔ Antibiotics & Eye Drops: Prevent infection and keep the eyes lubricated.
✔ Avoid Heavy Lifting & Strenuous Activity: For at least 4 weeks after surgery.
✔ Follow-Up Appointments: Your doctor will monitor healing and adjust treatment if needed.
⚠ Temporary swelling, bruising, or blurry vision – Common and improves in a few weeks.
⚠ Mild eye dryness or irritation – Can be managed with lubricating eye drops.
⚠ Double vision may persist – Some cases require additional adjustments.
⚠ Scarring (minimal and hidden when possible).
⚠ Rare risks include infection or bleeding, but these are preventable with proper care.
✅ Significant improvement in eye bulging and eyelid positioning.
✅ Reduced pressure on the eye, leading to better vision and comfort.
✅ Improved facial symmetry and natural eye appearance.
✅ Most patients see final results within 3-6 months.
✔ If the surgery is performed for medical reasons (e.g., to improve vision, reduce eye bulging, or prevent optic nerve damage), insurance may cover part or all of the procedure.
✔ Cosmetic-related procedures are usually not covered.
Most TED cases remain stable after surgery, but if thyroid levels fluctuate or smoking continues, symptoms may return.
🚨 Severe cases can lead to:
If you experience severe eye bulging, double vision, or eyelid problems due to thyroid eye disease, consult an oculoplastic surgeon or orbital specialist to explore surgical treatment options.
💡 Surgical treatment for Thyroid Eye Disease can restore vision, improve eye comfort, and enhance facial appearance.
✅ Most patients experience significant improvements within months, with lasting results.
📌 If you have persistent TED symptoms, seek expert medical evaluation to determine the best treatment plan.
Thyroid Orbitopathy, also known as Thyroid Eye Disease (TED) or Graves’ Orbitopathy, is an autoimmune condition where the immune system mistakenly attacks the tissues around the eyes. This leads to inflammation, swelling, and tissue expansion, causing symptoms like eye bulging (proptosis), double vision, eyelid retraction, and eye discomfort.
TED is mainly caused by an overactive thyroid due to Graves’ Disease. However, some cases occur in patients with normal or underactive thyroid function. Factors that contribute to TED include:
✔ Overactive thyroid (Hyperthyroidism/Graves’ Disease) – The most common cause.
✔ Smoking – Greatly increases the risk and severity of TED.
✔ Autoimmune response – The body mistakenly attacks tissues around the eyes.
✔ Genetics – Family history may play a role.
⚠ Bulging Eyes (Proptosis) – The eyes appear pushed forward due to swelling.
⚠ Eyelid Retraction – The eyelids are pulled too high or too low.
⚠ Double Vision (Diplopia) – Difficulty aligning both eyes, causing blurred vision.
⚠ Eye Redness & Swelling – The eyes may feel irritated and look inflamed.
⚠ Dry Eyes & Light Sensitivity – TED can cause excessive tearing, grittiness, and discomfort.
⚠ Vision Changes – In severe cases, TED can affect the optic nerve, leading to vision loss.
A doctor may perform:
✔ Physical Eye Exam – To check for swelling, redness, eye movement, and bulging.
✔ Imaging Tests (CT/MRI) – To assess the swelling and pressure behind the eyes.
✔ Thyroid Blood Tests – To check thyroid hormone levels (TSH, T3, T4, and thyroid antibodies).
🚨 There is no cure, but treatments can manage symptoms, reduce inflammation, and prevent vision loss.
TED treatment depends on whether the disease is active (inflamed phase) or stable (chronic phase).
🔹 Thyroid Hormone Control – Proper thyroid management can help reduce TED severity.
🔹 Teprotumumab (Tepezza®) – An FDA-approved infusion therapy that reduces eye bulging and inflammation.
🔹 Steroids (Corticosteroids) – Reduce swelling and pressure around the eyes.
🔹 Eye Lubrication (Artificial Tears & Ointments) – Helps relieve dryness and irritation.
🔹 Prism Glasses – Helps with double vision (diplopia).
🔹 Smoking Cessation – Stopping smoking greatly improves TED symptoms.
🔹 Orbital Decompression Surgery – Removes bone or fat from the eye socket to reduce bulging.
🔹 Strabismus Surgery (Eye Muscle Surgery) – Corrects double vision by adjusting misaligned eye muscles.
🔹 Eyelid Surgery – Corrects eyelid retraction to improve eye comfort and closure.
⏳ The active (inflammatory) phase lasts 6 months to 2 years.
✔ Once TED stabilizes, surgery may be needed to correct lingering issues.
Yes, but it is more common for TED to affect both eyes. One eye may have more severe symptoms than the other.
🚨 If severe TED is not treated, it can lead to:
✔ Most insurance plans cover TED treatments, including:
Yes, TED can relapse, especially if thyroid levels are not well controlled or the patient continues smoking.
✔ Quit Smoking – This is the most effective way to slow TED progression.
✔ Manage Thyroid Levels – Follow endocrinologist-recommended treatments.
✔ Wear Sunglasses & Lubricate Eyes – Protect your eyes from dryness and irritation.
✔ Get Regular Eye Checkups – Early detection helps prevent complications.
If you experience eye bulging, double vision, or eye discomfort, consult an oculoplastic surgeon or endocrinologist to discuss treatment options.
💡 Thyroid Eye Disease is a progressive condition that requires early diagnosis and treatment to prevent permanent eye changes.
✅ With new treatments like Tepezza and surgical corrections, most patients experience significant improvement.
📌 If you have symptoms of TED, seek medical attention to prevent complications and protect your vision.